Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Yifeng Lei; Lixue Tang; Yangzhouyun Xie; Yunlei Xianyu; Lingmin Zhang; Peng Wang; Yoh Hamada; Kai Jiang; Wenfu Zheng; Xingyu Jiang

doi:10.1038/ncomms15130

Nature Communications (Apr 2017)

Gold nanoclusters-assisted delivery of NGF siRNA for effective treatment of pancreatic cancer

Yifeng Lei,
Lixue Tang,
Yangzhouyun Xie,
Yunlei Xianyu,
Lingmin Zhang,
Peng Wang,
Yoh Hamada,
Kai Jiang,
Wenfu Zheng,
Xingyu Jiang

Affiliations

Yifeng Lei: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Lixue Tang: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Yangzhouyun Xie: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Yunlei Xianyu: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Lingmin Zhang: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Peng Wang: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Yoh Hamada: Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University
Kai Jiang: Department of Hepatobiliary Surgery, Chinese PLA General Hospital
Wenfu Zheng: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology
Xingyu Jiang: Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for NanoScience and Technology

DOI: https://doi.org/10.1038/ncomms15130
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 15

Abstract

Read online

Nerve growth factor (NGF) contributes to the sustained growth and metastasis of pancreatic cancer cells. Here, the authors develop a gold nanocluster-coupled siRNA against NGF that efficiently silences theNGFgene and inhibits tumour growth of pancreatic cancer in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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