DLP printing of hydrogel/calcium phosphate composites for the treatment of bone defects

I.I. Preobrazhenskiy; A.A. Tikhonov; P.V. Evdokimov; A.V. Shibaev; V.I. Putlyaev

Open Ceramics (Jun 2021)

DLP printing of hydrogel/calcium phosphate composites for the treatment of bone defects

I.I. Preobrazhenskiy,
A.A. Tikhonov,
P.V. Evdokimov,
A.V. Shibaev,
V.I. Putlyaev

Affiliations

I.I. Preobrazhenskiy: Materials Science Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia; Corresponding author.
A.A. Tikhonov: Materials Science Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia
P.V. Evdokimov: Materials Science Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia; Kurnakov Institute of General and Inorganic Chemistry of RAS, 119991, Leninsky Prospect 31, Moscow, Russia
A.V. Shibaev: Physics Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia
V.I. Putlyaev: Materials Science Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia; Chemistry Department, Lomonosov Moscow State University, 119991, Leninskie Gory 1, Moscow, Russia

Journal volume & issue: Vol. 6
p. 100115

Abstract

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In this work, biocomposites based on hydrogels filled with calcium phosphates were fabricated using DLP method of 3D printing for the treatment of bone defects. The possibility to tune the functional properties of hydrogels such as degradation, swelling, and mechanical behavior by using a mixture of monomers with different functionality and different calcium phosphates was shown. Mechanical properties, photopolymerization, swelling behavior, and microstructure of hydrogels based on a mixture of poly(ethylene glycol) methacrylate/poly(ethylene glycol) diacrylate (PEGMA/PEGDA) monomers with different composition were studied. It was found that the usage of α-tricalcium phosphate (α-TCP) powder as a filler for hydrogels allowed to increase the filler fraction up to 60 wt% in comparison with octacalcium phosphate (OCP) and brushite (10 wt%) without significant thickening of photosuspension for DLP printing. Finally, the main parameters of DLP printing for biocomposites based on PEGMA/PEGDA hydrogels were found, and the macroporous biocomposite filled with 60 wt% α-TCP with gyroid structure was obtained.

Published in Open Ceramics

ISSN: 2666-5395 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Technology: Chemical technology: Clay industries. Ceramics. Glass
Website: https://www.journals.elsevier.com/open-ceramics

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