Communications Biology (Apr 2021)

Ecological niche adaptation of Salmonella Typhimurium U288 is associated with altered pathogenicity and reduced zoonotic potential

  • Mark Kirkwood,
  • Prerna Vohra,
  • Matt Bawn,
  • Gaëtan Thilliez,
  • Hannah Pye,
  • Jennifer Tanner,
  • Cosmin Chintoan-Uta,
  • Priscilla Branchu,
  • Liljana Petrovska,
  • Timothy Dallman,
  • Neil Hall,
  • Mark P. Stevens,
  • Robert A. Kingsley

DOI
https://doi.org/10.1038/s42003-021-02013-4
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 15

Abstract

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Mark Kirkwood et al. take an epidemiological, genomic, phylogenetic, and experimental approach to assess the evolutionary origins and virulence of the U288 and ST34 isolates of Salmonella enterica in affecting livestock and potentially humans. Their results indicate that the molecular evolution of these isolates is associated with altered pathogenicity in pigs and reduced zoonotic potential of U288.