Plasmids Shape the Current Prevalence of <i>tmexCD1-toprJ1</i> among Klebsiella pneumoniae in Food Production Chains

Abstract

Tigecycline, the first member of the glycylcycline class of antibacterial agents, is frequently used to treat complicated infections caused by multidrug-resistant Gram-positive and Gram-negative bacteria. The emergence of a novel plasmid-mediated efflux pump, TmexCD1-ToprJ1, conferring resistance to multiple antimicrobials, including tigecycline, poses a huge risk to human health.