Nature Communications (Jul 2020)
The chromatin remodeling enzyme Chd4 regulates genome architecture in the mouse brain
Abstract
The mechanisms underlying gene regulation and genome architecture remain poorly understood. Here, the authors investigate the role of chromatin remodelling enzyme Chd4 in granule neurons of the mouse cerebellum and find that conditional knockout of Chd4 preferentially activates enhancers and modulates genome architecture at a genome-wide level.
