Фармакоэкономика (Sep 2016)

EPIDEMIOLOGICAL FEATURES OF NON-ALCOHOLIC FATTY LIVER DISEASE IN NOVOSIBIRSK (SIBERIAN FEDERAL DISTRICT): REGIONAL DATA OF OPEN MULTICENTER PROSPECTIVE STUDY DIREG 2

  • V. V. Tsukanov,
  • A. S. Yurkina,
  • T. A. Ushakova,
  • D. V. Blinov

DOI
https://doi.org/10.17749/2070-4909.2016.9.2.017-027
Journal volume & issue
Vol. 9, no. 2
pp. 17 – 27

Abstract

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Non-alcoholic fatty liver disease (NAFLD) is an important medical and social problem. Essentially, it can be attributed to the problems of interdisciplinary, since it involves issues related to insulin resistance, metabolic syndrome, dyslipidemia. Due to erased clinical manifestation of nonalcoholic fatty liver disease often is diagnosed at late stages of the disease — fibrosis and cirrhosis. The lack of epidemiological data in Russia has identified the need for a larger study to research the prevalence of NAFLD in the Russian Federation. DIREG 2 was the most extensive epidemiological study on the subject, which is coordinated by the leading experts in partnership with Sanofi Russia.Objective: to estimate the prevalence of NAFLD within the general practitioner’s and gastroenterologist’s patient flow. It is important to know current prevalence of NAFLD in Novosibirsk (Siberian Federal district) and to compare with DIREG 2 results.Materials and methods. Epidemiologic, observational, multicenter study assessing the prevalence of NAFLD among patients outpatient practice. A total of 50145 patients (3220 in Novosibirsk) including those suspected of having NAFLD criteria were enrolled in the Program. The investigators were qualified doctors (GPs \ therapist’s \ gastroenterologists), providing outpatient care for the population. The epidemiological data were obtained, recorded during two routine patient visits to investigating centers.Study results. Percentage of patients with revealed NAFLD within the patient flow primary or consistently coming to selected doctors for any reason including those suspected of having NAFLD was 37.3% in Russia vs 56.9% in Novosibirsk (Siberian Federal district).Conclusion. Prevalence of NAFLD among patient flow of doctors in Russia is quite high. It has been revealed a high prevalence of NANCFLD within the patient flow primary or consistently coming to selected by doctors for any reason.

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