Application of nanomedical technology in breast cancer treatment

Abstract

Introduction: Despite the progress in breast cancer treatment, currently used methods are often aggressive and with low selectivity, thus inducing systemic toxicity while obtaining limited effect. The application of nanotechnologies is a promising novel technology, which could overcome these limitations. Corresponding section headings: Incorporation of the medication into a nanocarrier enables the administration of molecules with the suboptimal pharmacokinetic profiles if given as free agents. Furthermore, nanomedicine could improve the safety profile of currently used chemotherapeutics, by modifying pharmacokinetic properties and prolonging the half-life of the therapeutic. Most importantly, it provides a possibility of designing drug carriers with selective delivery to malignant cells, based on their characteristics. Conclusion: This advantage initiated an entirely new subset of targeted breast cancer therapy development, and has demonstrated favorable outcomes even in treatment of aggressive malignant types, metastatic developments, and multi-drug resistance.

Keywords

• breast cancer
• nanomedicine
• molecular targeted therapy
• nanoparticles
• drug carriers