Plasticity in visual cortex is disrupted in a mouse model of tauopathy

Abstract

Amalia Papanikolaou and Fabio Rodrigues et al. examine visual cortical function and intrinsic plasticity using the rTg4510 tauopathy mouse model. They demonstrate that, while basal visual cortical responses seem largely unaffected, intrinsic plasticity and the behavioural response to a visual stimulus is compromised, even in young rTg4510 mice.