Formulation and Evaluation of Trimetazidine Hydrochloride Loaded Solid Lipid Nanoparticles

Abstract

Objective The aim of the current study was to design trimetazidine hydrochloride solid lipid nano-particles SLNs and to evaluate them.Methods Hot homogenization technique was used for preparation of trimetazidine hydrochloride SLNs using different lipids Tristearin GMS and Compritol soy lecithin as stabilizers and Tween 80 Poloxamer as surfactants. Results The nano-particles were characterized for particle size polydispersity index PDI zeta potential entrapment efficiency and drug release patterns. Particle sizes ranged from 145.6 to 780.1 nm. All formulations showed PDI from 0.170 to 0.358. The zeta potential ranged from -24.2 to -38.0 mV trimetazidine SLNs demonstrated entrapment efficiency ranging from 84.42 to 93.82. The cumulative percentage release of drug from different trimetazidine hydrochloride nano- particles ranged from 75.43 to 93.59 depending upon nature and quantity of lipid used. Conclusion Among all the formulations F1 showed highest drug release of 93.59 and was considered as optimized formulation. Drug release was found to follow first order diffusion control and the lsquonrsquo value obtained from the Korsmeyer Pepparsquos model indicated anomalous diffusion non-Fickian type n value of F1 was 0.5716 as release mechanism. The particle size PDI and zeta potential of optimized formulation were found to be 153.8 nm 0.358 -38.0 mV respectively.