Morin mitigate diethyl phthalate and bisphenol s – Induced hematotoxicity in rats model by abrogating oxidative stress

Abstract

Endocrine disruptors affect biological systems, some as neglected home producing toxicity (NHPT). We investigated the effect of morin on diethyl phthalate (DEP) and bisphenol S (BPS)-induced hematotoxicity and oxidative stress using a rat model. Rats were exposed to DEP (50 μg/kg) and BPS (200 μg/kg) and treated with morin (25 and 50 mg/kg) by oral gavage for twenty-one days. Afterwards, they were sacrificed. Morin treatment significantly (p < 0.05) protected red blood cells and plasma membrane architecture by abolishing the DEP+BPS-induced decrease in the activity of all the hematological indices. Co-treatment with morin remarkably (p < 0.05) reversed DEP+BPS-induced decreases in glutathione levels, CAT, GPx, and SOD activities in red blood cells, while attenuating DEP+BPS mediated increase in hemato-oxidative damage markers (MDA and NO levels). Collectively, the different acute doses of morin might avert DEP and BPS-mediated hematotoxicity dysfunctions via its antioxidant, free-radical scavenging effect.

Keywords

• Diethyl phthalate
• Bisphenol S
• Hematotoxicity
• Morin
• Oxidative stress
• Antioxidant