Synthetic Methods and Pharmacological Potentials of Triazolothiadiazines: A Review

Abstract

This review article examines the synthetic pathways for triazolothiadiazine derivatives, such as triazolo[3,4-b]thiadiazines, triazolo[5,1-b]thiadiazines, and triazolo[4,3-c]thiadiazines, originating from triazole derivatives, thiadiazine derivatives, or thiocarbohydrazide. The triazolothiadiazine derivatives exhibit several biological actions, including antibacterial, anticancer, antiviral, antiproliferative, analgesic, anti-inflammatory, and antioxidant properties. The review article aims to assist researchers in creating new biologically active compounds for designing target-oriented triazolothiadiazine-based medicines to treat multifunctional disorders.

Keywords

• triazolo[3,4-<i>b</i>]thiadiazines
• triazolo[5,1-<i>b</i>]thiadiazines
• triazolo[4,3-<i>c</i>]thiadiazines triazol
• thiadiazine
• thiocarbohydrazide
• biological activity