PLoS ONE (Jan 2017)

Statin improves survival in patients with EGFR-TKI lung cancer: A nationwide population-based study.

  • Ming-Szu Hung,
  • I-Chuan Chen,
  • Chuan-Pin Lee,
  • Ru-Jiun Huang,
  • Pau-Chung Chen,
  • Ying-Huang Tsai,
  • Yao-Hsu Yang

DOI
https://doi.org/10.1371/journal.pone.0171137
Journal volume & issue
Vol. 12, no. 2
p. e0171137

Abstract

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Long-term use of statins has been reported to reduce the risk of death in patients with lung cancer. This study investigated the effect of statin use among patients with lung cancer receiving epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKIs) therapy. A nationwide, population-based case-control study was conducted using the Taiwan National Health Insurance Research Database. From January 1, 1997 to December 31, 2012, a total of 1,707 statin and 6,828 non-statin matched lung cancer cohorts with EGFR-TKIs treatment were studied. Statin use was associated with a reduced risk of death (HR: 0.58, 95% CI: 0.54-0.62, p < 0.001). In addition, statin use was associated with a significantly longer median progression-free survival (8.3 months, 95% CI: 7.6-8.9 vs. 6.1 months, 95% CI: 6.0-6.4, p < 0.001) and median overall survival (35.5 months, 95% CI: 33.8-38.1 vs. 23.9 months, 95% CI: 23.4-24.7, p < 0.001). In conclusion, statins might potentially enhance the therapeutic effect and increase survival in patients with lung cancer receiving EGFR-TKI therapy.