The procedure for extracting and purifying Rotudin from tubers of (Stephania rotunda Lour.) grown in Hoa Binh province

Abstract

Tubers of Stephania rotunda Lour. grown in Hoa Binh province are used as raw materials for extracting l-tetrahydropalmatine (a medical jargon-Rotundin) C21H25NO4 - a major component - alkaloid with the effects of sedative and preventing loss of memory. The purpose of this research is to study a simple, inexpensive, and efficient procedure for extracting rotudin. - Maceration method of 1/6 of dried powder of tubers with 1% H2SO4 solution gives the highest yield of 0.35% on the extraction. The purity of rotudin is 98% on HPLC. - The chemical structure of rotudin was confirmed by NMR data.

Keywords

• chiết xuất, l-tetrahydropalmatine, nmr, rotudin, stephania rotunda