Nature Communications (Feb 2018)

Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes

  • Zhishi Ye,
  • Sarju Adhikari,
  • Yu Xia,
  • Mingji Dai

DOI
https://doi.org/10.1038/s41467-018-03085-3
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Saturated N-heterocycle rings are common structural motifs of many FDA-approved drugs. Here, the authors show that a metal-free amphoteric diamination of allenes produces valuable six-, seven- and eight-membered N-heterocycles with high diversity and tolerance of functional groups on the ring.