Nature Communications (Feb 2018)
Expedient syntheses of N-heterocycles via intermolecular amphoteric diamination of allenes
Abstract
Saturated N-heterocycle rings are common structural motifs of many FDA-approved drugs. Here, the authors show that a metal-free amphoteric diamination of allenes produces valuable six-, seven- and eight-membered N-heterocycles with high diversity and tolerance of functional groups on the ring.