Nature Communications (Sep 2020)
Macrophage secretion of miR-106b-5p causes renin-dependent hypertension
- J. Oh,
- S. J. Matkovich,
- A. E. Riek,
- S. M. Bindom,
- J. S. Shao,
- R. D. Head,
- R. A. Barve,
- M. S. Sands,
- G. Carmeliet,
- P. Osei-Owusu,
- R. H. Knutsen,
- H. Zhang,
- K. J. Blumer,
- C. G. Nichols,
- R. P. Mecham,
- Á Baldán,
- B. A. Benitez,
- M. L. Sequeira-Lopez,
- R. A. Gomez,
- C. Bernal-Mizrachi
Affiliations
- J. Oh
- Department of Medicine, Washington University School of Medicine
- S. J. Matkovich
- Department of Medicine, Washington University School of Medicine
- A. E. Riek
- Department of Medicine, Washington University School of Medicine
- S. M. Bindom
- Department of Pediatrics, Washington University School of Medicine
- J. S. Shao
- Department of Medicine, Washington University School of Medicine
- R. D. Head
- Department of Genetics, Washington University School of Medicine
- R. A. Barve
- Department of Genetics, Washington University School of Medicine
- M. S. Sands
- Department of Medicine, Washington University School of Medicine
- G. Carmeliet
- Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases, Metabolism, and Aging, KU Leuven
- P. Osei-Owusu
- Department of Cell Biology and Physiology, Washington University School of Medicine
- R. H. Knutsen
- Department of Cell Biology and Physiology, Washington University School of Medicine
- H. Zhang
- Department of Cell Biology and Physiology, Washington University School of Medicine
- K. J. Blumer
- Department of Cell Biology and Physiology, Washington University School of Medicine
- C. G. Nichols
- Department of Cell Biology and Physiology, Washington University School of Medicine
- R. P. Mecham
- Department of Cell Biology and Physiology, Washington University School of Medicine
- Á Baldán
- Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University
- B. A. Benitez
- Department of Psychiatry, Washington University School of Medicine
- M. L. Sequeira-Lopez
- Department of Pediatrics, University of Virginia School of Medicine
- R. A. Gomez
- Department of Pediatrics, University of Virginia School of Medicine
- C. Bernal-Mizrachi
- Department of Medicine, Washington University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-18538-x
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Myeloid cells are involved in hypertension, but their exact role in renin-induced hypertension remains unclear. Here the authors show that impaired vitamin D signaling in myeloid cells causes hypertension via macrophage-specific miR-106b-5p secretion, which activates renin production in the kidney.
