Nature Communications (Aug 2020)
Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
- Claudie Bosc,
- Nicolas Broin,
- Marjorie Fanjul,
- Estelle Saland,
- Thomas Farge,
- Charly Courdy,
- Aurélie Batut,
- Rawand Masoud,
- Clément Larrue,
- Sarah Skuli,
- Nicolas Espagnolle,
- Jean-Christophe Pagès,
- Alice Carrier,
- Frédéric Bost,
- Justine Bertrand-Michel,
- Jérôme Tamburini,
- Christian Récher,
- Sarah Bertoli,
- Véronique Mansat-De Mas,
- Stéphane Manenti,
- Jean-Emmanuel Sarry,
- Carine Joffre
Affiliations
- Claudie Bosc
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Nicolas Broin
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Marjorie Fanjul
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Estelle Saland
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Thomas Farge
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Charly Courdy
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Aurélie Batut
- MetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics
- Rawand Masoud
- Aix Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille
- Clément Larrue
- Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva
- Sarah Skuli
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Nicolas Espagnolle
- STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS
- Jean-Christophe Pagès
- STROMALab, Université de Toulouse, CNRS ERL5311, EFS, INP-ENVT, Inserm U1031, UPS
- Alice Carrier
- Aix Marseille Université, CNRS, INSERM, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille
- Frédéric Bost
- Inserm U1065, C3M, Team Cellular and Molecular Physiopathology of Obesity and Diabetes, Université Nice Côte d’Azur, Inserm
- Justine Bertrand-Michel
- MetaToul-MetaboHUB, National Infrastructure of Metabolomics and Fluxomics
- Jérôme Tamburini
- Translational Research Centre in Onco-hematology, Faculty of Medicine, University of Geneva
- Christian Récher
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Sarah Bertoli
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Véronique Mansat-De Mas
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Stéphane Manenti
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Jean-Emmanuel Sarry
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- Carine Joffre
- Cancer Research Center of Toulouse (CRCT), INSERM U1037, CNRS ERL5294, University of Toulouse
- DOI
- https://doi.org/10.1038/s41467-020-17882-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
How autophagy supports tumor cell metabolism is not fully clear. Here, the authors show that autophagy regulates lipid availability to support mitochondrial oxidative metabolism through mitochondria-endoplasmic reticulum contact sites, necessary for cell proliferation in AML.
