Structural basis of adenylyl cyclase 9 activation

Chao Qi; Pia Lavriha; Ved Mehta; Basavraj Khanppnavar; Inayathulla Mohammed; Yong Li; Michalis Lazaratos; Jonas V. Schaefer; Birgit Dreier; Andreas Plückthun; Ana-Nicoleta Bondar; Carmen W. Dessauer; Volodymyr M. Korkhov

doi:10.1038/s41467-022-28685-y

Nature Communications (Feb 2022)

Structural basis of adenylyl cyclase 9 activation

Chao Qi,
Pia Lavriha,
Ved Mehta,
Basavraj Khanppnavar,
Inayathulla Mohammed,
Yong Li,
Michalis Lazaratos,
Jonas V. Schaefer,
Birgit Dreier,
Andreas Plückthun,
Ana-Nicoleta Bondar,
Carmen W. Dessauer,
Volodymyr M. Korkhov

Affiliations

Chao Qi: Institute of Molecular Biology and Biophysics, ETH
Pia Lavriha: Laboratory of Biomolecular Research, Division of Biology and Chemistry, Paul Scherrer Institute
Ved Mehta: Institute of Molecular Biology and Biophysics, ETH
Basavraj Khanppnavar: Institute of Molecular Biology and Biophysics, ETH
Inayathulla Mohammed: Biozentrum, University of Basel
Yong Li: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Michalis Lazaratos: Department of Physics, Theoretical Molecular Biophysics Group, Freie Universität Berlin
Jonas V. Schaefer: Department of Biochemistry, University of Zurich
Birgit Dreier: Department of Biochemistry, University of Zurich
Andreas Plückthun: Department of Biochemistry, University of Zurich
Ana-Nicoleta Bondar: Department of Physics, Theoretical Molecular Biophysics Group, Freie Universität Berlin
Carmen W. Dessauer: Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center
Volodymyr M. Korkhov: Institute of Molecular Biology and Biophysics, ETH

DOI: https://doi.org/10.1038/s41467-022-28685-y
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 11

Abstract

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Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzymes, AC9.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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