Treating Leaky Syndrome in the Over 65s: Progress and Challenges

Abstract

Shalini Jain,1,2 Francesco Marotta,3 Leila Haghshenas,4 Hariom Yadav1,2,5 1Department of Neurosurgery and Brain Repair, University of South Florida, Tampa, FL, USA; 2USF Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL, USA; 3ReGenera R&D International for Aging Intervention, Milano, Italy; 4Department of Clinical Bioinformatics, Harvard Medical School, Boston, MA, USA; 5Department of Internal Medicine- Digestive Diseases and Nutrition, University of South Florida, Tampa, FL, USACorrespondence: Shalini Jain, Department of Neurosurgery and Brain Repair, University of South Florida, 12901 Bruce B Downs Blvd, MDC 78, Tampa, FL, 33612, USA, Email [email protected] Francesco Marotta, ReGenera R&D International for Aging Intervention and Chair of Longevity & Vitality in Medical Science Commission, FEMTEC World Federation, Milano, Italy, Email [email protected]: As we age, our organ functions gradually decline. Circulating factors in the blood and the integrity of organ barriers can become dysfunctional, resulting in a condition known as leaky syndrome. This condition involves the unregulated exchange or leakage of components between organs. However, the triggers of leaky syndrome, as well as its role in aging-related disorders and illnesses, remain largely unknown. In this editorial, we discuss potential mechanisms that originate from the gut and resident microbes (microbiome) to contribute in leaky syndrome. Furthermore, we explore how the food we consume can impact the development of leaky syndrome, potentially influencing the biology of aging and challenges to diagnose the leaky gut condition accurately and clinically.Keywords: leaky, gut, syndrome, microbiome, inflammation, barrier

Keywords

• leaky
• gut
• syndrome
• microbiome
• inflammation
• barrier