Nature Communications (Jul 2021)
Immune responses to a single dose of the AZD1222/Covishield vaccine in health care workers
- Chandima Jeewandara,
- Achala Kamaladasa,
- Pradeep Darshana Pushpakumara,
- Deshni Jayathilaka,
- Inoka Sepali Aberathna,
- Danasekara Rallage Saubhagya Rasikangani Danasekara,
- Dinuka Guruge,
- Thushali Ranasinghe,
- Shashika Dayarathna,
- Thilagaraj Pathmanathan,
- Gayasha Somathilake,
- Panambara Arachchige Deshan Madhusanka,
- Shyrar Tanussiya Ramu,
- Tibutius Thanesh Pramanayagam Jayadas,
- Heshan Kuruppu,
- Ayesha Wijesinghe,
- Herath Mudiyanselage Thashmi Nimasha,
- Dushantha Milroy,
- Achini Anuja Nandasena,
- Poththawela Kankanam Gamage Nilanka Sanjeewani,
- Ruwan Wijayamuni,
- Sudath Samaraweera,
- Lisa Schimanski,
- T. K. Tan,
- Tao Dong,
- Graham S. Ogg,
- Alain Townsend,
- Gathsaurie Neelika Malavige
Affiliations
- Chandima Jeewandara
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Achala Kamaladasa
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Pradeep Darshana Pushpakumara
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Deshni Jayathilaka
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Inoka Sepali Aberathna
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Danasekara Rallage Saubhagya Rasikangani Danasekara
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Dinuka Guruge
- Colombo Municipal Council
- Thushali Ranasinghe
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Shashika Dayarathna
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Thilagaraj Pathmanathan
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Gayasha Somathilake
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Panambara Arachchige Deshan Madhusanka
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Shyrar Tanussiya Ramu
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Tibutius Thanesh Pramanayagam Jayadas
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Heshan Kuruppu
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Ayesha Wijesinghe
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Herath Mudiyanselage Thashmi Nimasha
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- Dushantha Milroy
- Base Hospital
- Achini Anuja Nandasena
- Department of Family Medicine, University of Sri Jayewardenepura
- Poththawela Kankanam Gamage Nilanka Sanjeewani
- Department of Family Medicine, University of Sri Jayewardenepura
- Ruwan Wijayamuni
- Colombo Municipal Council
- Sudath Samaraweera
- Epidemiology Unit, Ministry of Health Sri Lanka
- Lisa Schimanski
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- T. K. Tan
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Tao Dong
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Graham S. Ogg
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Alain Townsend
- MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
- Gathsaurie Neelika Malavige
- Allergy Immunology and Cell Biology Unit, Department of Immunology and Molecular Medicine, University of Sri Jayewardenepura
- DOI
- https://doi.org/10.1038/s41467-021-24579-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 9
Abstract
Here the authors show in a large cohort of healthcare workers that one dose of the AZD1222 vaccine seroconverts 92.9% of vaccinees, irrespective of age and gender, and results in high antibody titers to wild-type SARS-CoV-2 but only low titers to the B.1.351 variant.
