Inhibition of MRN activity by a telomere protein motif

Freddy Khayat; Elda Cannavo; Majedh Alshmery; William R. Foster; Charly Chahwan; Martino Maddalena; Christopher Smith; Antony W. Oliver; Adam T. Watson; Antony M. Carr; Petr Cejka; Alessandro Bianchi

doi:10.1038/s41467-021-24047-2

Nature Communications (Jun 2021)

Inhibition of MRN activity by a telomere protein motif

Freddy Khayat,
Elda Cannavo,
Majedh Alshmery,
William R. Foster,
Charly Chahwan,
Martino Maddalena,
Christopher Smith,
Antony W. Oliver,
Adam T. Watson,
Antony M. Carr,
Petr Cejka,
Alessandro Bianchi

Affiliations

Freddy Khayat: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Elda Cannavo: Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI)
Majedh Alshmery: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
William R. Foster: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Charly Chahwan: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Martino Maddalena: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Christopher Smith: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Antony W. Oliver: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Adam T. Watson: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Antony M. Carr: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex
Petr Cejka: Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università della Svizzera italiana (USI)
Alessandro Bianchi: Genome Damage and Stability Centre, School of Life Sciences, University of Sussex

DOI: https://doi.org/10.1038/s41467-021-24047-2
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Telomeres suppress the DNA damage response at chromosome ends. Here the authors show that in budding yeast the activity of the MRX complex in DNA repair and DNA damage signaling is inhibited by telomeric protein Rif2 via a short motif at the N-terminus.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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