The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

Jia-Nan Mo; Junqi Su; Jiannan Zhao

doi:10.3390/molecules24071216

Molecules (Mar 2019)

The Asymmetric A<sup>3</sup>(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines

Jia-Nan Mo,
Junqi Su,
Jiannan Zhao

Affiliations

Jia-Nan Mo: Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China
Junqi Su: Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China
Jiannan Zhao: Zhang Dayu School of Chemistry, Dalian University of Technology, Dalian 116024, China

DOI: https://doi.org/10.3390/molecules24071216
Journal volume & issue: Vol. 24, no. 7
p. 1216

Abstract

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The recent developments in asymmetric A3 (aldehyde–alkyne–amine) coupling has been summarized in this review. Several interesting modifications of the ligands enabled the highly enantioselective synthesis of chiral propargylamines, which are further used in the construction of nitrogen-containing chiral building blocks.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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