Communications Biology (May 2022)
Human M1 macrophages express unique innate immune response genes after mycobacterial infection to defend against tuberculosis
- Arshad Khan,
- Kangling Zhang,
- Vipul K. Singh,
- Abhishek Mishra,
- Priyanka Kachroo,
- Tian Bing,
- Jong Hak Won,
- Arunmani Mani,
- Ramesha Papanna,
- Lovepreet K. Mann,
- Eder Ledezma-Campos,
- Genesis Aguillon-Duran,
- David H. Canaday,
- Sunil A. David,
- Blanca I. Restrepo,
- Nhung Nguyen Viet,
- Ha Phan,
- Edward A. Graviss,
- James M. Musser,
- Deepak Kaushal,
- Marie Claire Gauduin,
- Chinnaswamy Jagannath
Affiliations
- Arshad Khan
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- Kangling Zhang
- Department of Pharmacology and Toxicology, University of Texas Medical Branch
- Vipul K. Singh
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- Abhishek Mishra
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- Priyanka Kachroo
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- Tian Bing
- Department of Pharmacology and Toxicology, University of Texas Medical Branch
- Jong Hak Won
- Department of Obstetrics, Gynecology and Reproductive Sciences, UTHSC
- Arunmani Mani
- Department of Obstetrics, Gynecology and Reproductive Sciences, UTHSC
- Ramesha Papanna
- Department of Obstetrics, Gynecology and Reproductive Sciences, UTHSC
- Lovepreet K. Mann
- Department of Obstetrics, Gynecology and Reproductive Sciences, UTHSC
- Eder Ledezma-Campos
- Centro Regional de TB, Secretaría de Salud de Tamaulipas
- Genesis Aguillon-Duran
- Centro Regional de TB, Secretaría de Salud de Tamaulipas
- David H. Canaday
- Division of Infectious Disease, Case Western Reserve University Cleveland VA
- Sunil A. David
- Virovax, LLC, Adjuvant Division
- Blanca I. Restrepo
- UT School of Public Health, Brownsville, and STDOI, UT Rio Grande Valley
- Nhung Nguyen Viet
- National Lung Hospital
- Ha Phan
- Center for Promotion of Advancement of Society
- Edward A. Graviss
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- James M. Musser
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- Deepak Kaushal
- Southwest National Primate Research Center, Texas Biomedical Research Institute
- Marie Claire Gauduin
- Southwest National Primate Research Center, Texas Biomedical Research Institute
- Chinnaswamy Jagannath
- Department of Pathology and Genomic Medicine, Houston Methodist Research Institute, Weill-Cornell Medicine
- DOI
- https://doi.org/10.1038/s42003-022-03387-9
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 19
Abstract
Khan et al. use human blood and a macaque model of tuberculosis (TB) to assess whether macrophage heterogeneity contributes to TB immunity. They demonstrate that human macrophages show unique patterns of gene expression that enable differential control of TB after infection.
