Frontiers in Immunology (Dec 2020)

Glucocorticoid-Induced Leucine Zipper: A Promising Marker for Monitoring and Treating Sepsis

  • Ya-Jun He,
  • Ya-Jun He,
  • Ji-Qian Xu,
  • Ji-Qian Xu,
  • Miao-Miao Sun,
  • Miao-Miao Sun,
  • Xiang-Zhi Fang,
  • Xiang-Zhi Fang,
  • Zhe-Kang Peng,
  • Zhe-Kang Peng,
  • Shang-Wen Pan,
  • Shang-Wen Pan,
  • Ting Zhou,
  • Ting Zhou,
  • Ya-Xin Wang,
  • Ya-Xin Wang,
  • You Shang,
  • You Shang

DOI
https://doi.org/10.3389/fimmu.2020.606649
Journal volume & issue
Vol. 11

Abstract

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Sepsis is a clinical syndrome that resulting from a dysregulated inflammatory response to infection that leads to organ dysfunction. The dysregulated inflammatory response transitions from a hyper-inflammatory phase to a hypo-inflammatory or immunosuppressive phase. Currently, no phase-specific molecular-based therapies are available for monitoring the complex immune response and treating sepsis due to individual variations in the timing and overlap of the dysregulated immune response in most patients. Glucocorticoid-induced leucine zipper (GILZ), is broadly present in multiple tissues and circumvent glucocorticoid resistance (GCR) or unwanted side effects. Recently, the characteristics of GILZ downregulation during acute hyperinflammation and GILZ upregulation during the immunosuppressive phase in various inflammatory diseases have been well documented, and the protective effects of GILZ have gained attention in the field of sepsis. However, whether GILZ could be a promising candidate biomarker for monitoring and treating septic patients remains unknown. Here, we discuss the effect of GILZ in sepsis and sepsis-induced immunosuppression.

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