CDK4/6 inhibition in cancer: the cell cycle splicing connection

Abstract

Cyclin-dependent kinase −4 and −6 (CDK4/6) inhibitors are currently being assessed in clinical trials for the treatment of many cancers including melanoma. While investigating the mechanisms of CDK4/6 inhibitor resistance in melanoma, we uncovered a mechanism of action of these inhibitors in regulating the expression of both the mouse double minute 4 (MDM4) oncogene and tumor protein p53 (TP53).

Keywords

• cdk4
• cdk6
• melanoma
• acquired resistance
• prmt5
• mdm4
• tp53
• p21
• pre-mrna splicing