SECRETORY IMMUNOGLOBULIN A LEVEL IN SALIVA OF CHRONIC KIDNEY DISEASE PATIENTS ON DIALYSIS

Abstract

Dialysis patients have elevated levels of markers of inflammation. Endotoxin of gram negative bacteria is one of the most potent inducers of inflammation. Endotoxin translocation from the gut into the blood can triggerproinflammatory response. Secretory immunoglobulin A (sIgA) in the mucous membranes can neutralize bacterial toxins and prevent their translocation, if the immune response is adequate.

Keywords

• chronic kidney disease, peritoneal dialysis, hemodialysis, chronic inflammation, endotoxin, secretory immunoglobulin A, antiendotoxin secretory immunoglobulin A.