Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters

Haichao Liu; Vincent Ho Man Lau; Pan Xu; Tsz Hin Chan; Zhongxing Huang

doi:10.1038/s41467-022-32560-1

Nature Communications (Aug 2022)

Diverse synthesis of α-tertiary amines and tertiary alcohols via desymmetric reduction of malonic esters

Haichao Liu,
Vincent Ho Man Lau,
Pan Xu,
Tsz Hin Chan,
Zhongxing Huang

Affiliations

Haichao Liu: State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong
Vincent Ho Man Lau: State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong
Pan Xu: State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong
Tsz Hin Chan: State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong
Zhongxing Huang: State Key Laboratory of Synthetic Chemistry, Department of Chemistry, The University of Hong Kong

DOI: https://doi.org/10.1038/s41467-022-32560-1
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 8

Abstract

Read online

Chiral α-tertiary amines and tertiary alcohols are prevalent in bioactive molecules yet challenging targets to access. Here, the authors provide a dinuclear zinc-catalyzed desymmetric approach based on readily available malonic esters.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal