Communications Biology (Dec 2020)

Influenza virus neuraminidase regulates host CD8+ T-cell response in mice

  • Chung-Yi Wu,
  • Hong-Yang Chuang,
  • Chi-Huey Wong

DOI
https://doi.org/10.1038/s42003-020-01486-z
Journal volume & issue
Vol. 3, no. 1
pp. 1 – 10

Abstract

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Chung-Yi Wu et al. demonstrate a role of neuraminidase (NA) for Influenza A viruse (IAV)-specific CD8+ T-cell response and virion assembly. When mice are vaccinated with the live attenuated NA-defective IAV, they are protected from the upcoming IAV infection. This study provides insights into the development strategies of universal influenza vaccines.