Communications Biology (Jun 2021)
Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences
- Walter Rayford,
- Alp Tuna Beksac,
- Jordan Alger,
- Mohammed Alshalalfa,
- Mohsen Ahmed,
- Irtaza Khan,
- Ugo G. Falagario,
- Yang Liu,
- Elai Davicioni,
- Daniel E. Spratt,
- Edward M. Schaeffer,
- Felix Y. Feng,
- Brandon Mahal,
- Paul L. Nguyen,
- Robert B. Den,
- Mark D. Greenberger,
- Randy Bradley,
- Justin M. Watson,
- Matthew Beamer,
- Lambros Stamatakis,
- Darrell J. Carmen,
- Shivanshu Awasthi,
- Jonathan Hwang,
- Rachel Weil,
- Harri Merisaari,
- Nihal Mohamed,
- Leslie A. Deane,
- Dimple Chakravarty,
- Kamlesh K. Yadav,
- Kosj Yamoah,
- Sujit S. Nair,
- Ashutosh K. Tewari
Affiliations
- Walter Rayford
- The Urology Group LLC
- Alp Tuna Beksac
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Jordan Alger
- Department of Urology, Medstar Georgetown University Hospital
- Mohammed Alshalalfa
- Department of Radiation Oncology, University of California San Francisco
- Mohsen Ahmed
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Irtaza Khan
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Ugo G. Falagario
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Yang Liu
- Decipher Biosciences
- Elai Davicioni
- Decipher Biosciences
- Daniel E. Spratt
- Department of Radiation Oncology, University of Michigan
- Edward M. Schaeffer
- Department of Urology, Northwestern University
- Felix Y. Feng
- Department of Radiation Oncology, University of California San Francisco
- Brandon Mahal
- Department of Radiation Oncology, Brigham and Women’s Hospital
- Paul L. Nguyen
- Department of Radiation Oncology, Brigham and Women’s Hospital
- Robert B. Den
- Department of Radiation Oncology, Thomas Jefferson University
- Mark D. Greenberger
- The Urology Group LLC
- Randy Bradley
- Haslam College of Business, University of Tennessee
- Justin M. Watson
- WellStar Urology
- Matthew Beamer
- Department of Urology, Medstar Georgetown University Hospital
- Lambros Stamatakis
- Department of Urology, Medstar Georgetown University Hospital
- Darrell J. Carmen
- Georgia Urology
- Shivanshu Awasthi
- Department of Radiation Oncology, Moffitt Cancer Center
- Jonathan Hwang
- Department of Urology, Medstar Georgetown University Hospital
- Rachel Weil
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Harri Merisaari
- Department of Clinical Medicine, University of Turku
- Nihal Mohamed
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Leslie A. Deane
- Department of Urology, Rush University Medical Center
- Dimple Chakravarty
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Kamlesh K. Yadav
- Sema4, a Mount Sinai venture
- Kosj Yamoah
- Department of Radiation Oncology, Moffitt Cancer Center
- Sujit S. Nair
- Department of Urology, Icahn School of Medicine at Mount Sinai
- Ashutosh K. Tewari
- Department of Urology, Icahn School of Medicine at Mount Sinai
- DOI
- https://doi.org/10.1038/s42003-021-02140-y
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 9
Abstract
Walter Rayford, Alp Tuna Beksac et al. investigated gene expression alterations in African-American and European-American men who underwent radical prostatectomy for prostate cancer. The observed differences include higher expression of inflammation genes and lower expression of mismatch repair genes in African-American men.
