Neuropsychiatric Disease and Treatment (Feb 2022)

Validation of the Chinese Version of the Autism Diagnostic Interview-Revised in Autism Spectrum Disorder

  • Huang CF,
  • Lin YS,
  • Chiu YN,
  • Gau SSF,
  • Chen VCH,
  • Lin CF,
  • Hsieh YH,
  • Liu WS,
  • Chan HL,
  • Wu YY

Journal volume & issue
Vol. Volume 18
pp. 327 – 339

Abstract

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Chi-Fen Huang,1,2,* Yu-Siou Lin,1 Yen-Nan Chiu,3 Susan Shur-Fen Gau,3 Vincent Chin-Hung Chen,4,5 Chiao-Fan Lin,5,6 Yi-Hsuan Hsieh,5,6 Wen-Sheng Liu,7– 11 Hsiang-Lin Chan,5,6,* Yu-Yu Wu1 1Department of Psychiatry, YuNing Psychiatric Clinic, Taipei, Taiwan; 2Department of Psychiatry, Saint Paul’s Hospital, Taoyuan, Taiwan; 3Department of Psychiatry, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan; 4Department of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan; 5Department of Psychiatry, Chang Gung University, Taoyuan, Taiwan; 6Department of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan; 7Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; 8College of Science and Engineering, Fu Jen Catholic University, New Taipei City, Taiwan; 9Institute of Food Safety and Health Risk Assessment, National Yang Ming Chiao Tung University, Hsinchu, Taiwan; 10Division of Nephrology, Department of Medicine, Taipei City Hospital, Zhongxing Branch, Taipei, Taiwan; 11Department of Special Education, University of Taipei, Taipei, Taiwan*These authors contributed equally to this workCorrespondence: Yu-Yu Wu, Department of Psychiatry, YuNing Psychiatric Clinic, 3F., No. 6, Sec. 2, Fuxing S. Road, Taipei, 10664, Taiwan, Tel +886-2-27080706, Fax +886-2-27080987, Email [email protected]: The Autism Diagnostic Interview-Revised (ADI-R) is an essential semi-structured diagnostic tool for autism spectrum disorder (ASD). This study aims to validate the Chinese version of the ADI-R in Taiwan.Methods: The Chinese version of the ADI-R was translated and back-translated by professional translators and was approved by the original authors. A group of child psychiatrists and psychologists corrected medical terminology for the final version. Then, a total of 74 participants with ASD (male, 59, 79.73%) and 33 control participants without ASD (male, 16, 48.48%) were recruited. All participants were between 3 years 4 months to 41 years old (mean: 14.63 ± 7.93 years). Exploratory factor analysis (EFA) was used to measure the factor structure.Results: Cronbach’s α showed good to excellent internal consistency (0.78– 0.98) over the three core symptom domains of the Chinese version of the ADI-R. Pearson’s correlation analysis revealed very high test–retest reliability (Pearson’s correlation coefficients ranging from 0.95 to 0.99). EFA supported three categories of factors. For correct diagnosis of ASD, the Chinese version of the ADI-R had high sensitivity (97.30%), specificity (100%), positive predictive value (PPV) (100%), and negative predictive value (NPV) (94.29%). All domains also showed excellent area under the curves (0.991– 1), sensitivity (94.59– 98.65%), specificity (96.97– 100%), Youden index (94.59– 98.65%), PPV (97.78– 100%), NPV (89.19– 100%), positive likelihood ratio (32.55– 33.00%) and negative likelihood ratio (0.00– 0.05) after statistical examination.Conclusion: The Chinese version of the ADI-R is a reliable and valid diagnostic tool for the diagnosis of ASD in Clinical settings in Taiwan.Keywords: ADI-R, autism spectrum disorders, Chinese version, reliability, validity

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