Nature Communications (May 2018)

CE-BLAST makes it possible to compute antigenic similarity for newly emerging pathogens

  • Tianyi Qiu,
  • Yiyan Yang,
  • Jingxuan Qiu,
  • Yang Huang,
  • Tianlei Xu,
  • Han Xiao,
  • Dingfeng Wu,
  • Qingchen Zhang,
  • Chen Zhou,
  • Xiaoyan Zhang,
  • Kailin Tang,
  • Jianqing Xu,
  • Zhiwei Cao

DOI
https://doi.org/10.1038/s41467-018-04171-2
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 10

Abstract

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Sparse immune-binding data for emerging pathogens limits the ability of existing in silico antigenicity prediction methods to aid vaccine design. Here, the authors introduce a computational method that estimates antigenic pathogen similarity based on epitope structure.