Frontiers in Oncology (Jul 2022)
Clinical potential of the Hippo-YAP pathway in bladder cancer
- Xin Cheng,
- Xin Cheng,
- Xin Cheng,
- Kecheng Lou,
- Kecheng Lou,
- Kecheng Lou,
- Liang Ding,
- Liang Ding,
- Liang Ding,
- Xiaofeng Zou,
- Xiaofeng Zou,
- Xiaofeng Zou,
- Ruohui Huang,
- Ruohui Huang,
- Ruohui Huang,
- Gang Xu,
- Gang Xu,
- Gang Xu,
- Junrong Zou,
- Junrong Zou,
- Junrong Zou,
- Guoxi Zhang,
- Guoxi Zhang,
- Guoxi Zhang
Affiliations
- Xin Cheng
- First Clinical College, Gannan Medical University, Ganzhou, China
- Xin Cheng
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Xin Cheng
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Kecheng Lou
- First Clinical College, Gannan Medical University, Ganzhou, China
- Kecheng Lou
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Kecheng Lou
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Liang Ding
- First Clinical College, Gannan Medical University, Ganzhou, China
- Liang Ding
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Liang Ding
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Xiaofeng Zou
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Xiaofeng Zou
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Xiaofeng Zou
- Department of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, China
- Ruohui Huang
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Ruohui Huang
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Ruohui Huang
- Department of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, China
- Gang Xu
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Gang Xu
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Gang Xu
- Department of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, China
- Junrong Zou
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Junrong Zou
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Junrong Zou
- Department of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, China
- Guoxi Zhang
- Department of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Guoxi Zhang
- Institute of Urology, First Affiliated Hospital of Gannan Medical University, Ganzhou, China
- Guoxi Zhang
- Department of Jiangxi Engineering Technology Research Center of Calculi Prevention, Gannan Medical University, Ganzhou, China
- DOI
- https://doi.org/10.3389/fonc.2022.925278
- Journal volume & issue
-
Vol. 12
Abstract
Bladder cancer (BC) is one of the world’s most frequent cancers. Surgery coupled with adjuvant platinum-based chemotherapy is the current standard of therapy for BC. However, a high proportion of patients progressed to chemotherapy-resistant or even neoplasm recurrence. Hence, identifying novel treatment targets is critical for clinical treatment. Current studies indicated that the Hippo-YAP pathway plays a crucial in regulating the survival of cancer stem cells (CSCs), which is related to the progression and reoccurrence of a variety of cancers. In this review, we summarize the evidence that Hippo-YAP mediates the occurrence, progression and chemotherapy resistance in BC, as well as the role of the Hippo-YAP pathway in regulating bladder cancer stem-like cells (BCSCs). Finally, the clinical potential of Hippo-YAP in the treatment of BC was prospected.
Keywords
