Nature Communications (Sep 2018)
Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo
- Nina Derby,
- Manjari Lal,
- Meropi Aravantinou,
- Larisa Kizima,
- Patrick Barnable,
- Aixa Rodriguez,
- Manshun Lai,
- Asa Wesenberg,
- Shweta Ugaonkar,
- Keith Levendosky,
- Olga Mizenina,
- Kyle Kleinbeck,
- Jeffrey D. Lifson,
- M. Melissa Peet,
- Zachary Lloyd,
- Michael Benson,
- Walid Heneine,
- Barry R O’Keefe,
- Melissa Robbiani,
- Elena Martinelli,
- Brooke Grasperge,
- James Blanchard,
- Agegnehu Gettie,
- Natalia Teleshova,
- José A. Fernández-Romero,
- Thomas M. Zydowsky
Affiliations
- Nina Derby
- Center for Biomedical Research, Population Council
- Manjari Lal
- PATH
- Meropi Aravantinou
- Center for Biomedical Research, Population Council
- Larisa Kizima
- Center for Biomedical Research, Population Council
- Patrick Barnable
- Center for Biomedical Research, Population Council
- Aixa Rodriguez
- Center for Biomedical Research, Population Council
- Manshun Lai
- PATH
- Asa Wesenberg
- Center for Biomedical Research, Population Council
- Shweta Ugaonkar
- Center for Biomedical Research, Population Council
- Keith Levendosky
- Center for Biomedical Research, Population Council
- Olga Mizenina
- Center for Biomedical Research, Population Council
- Kyle Kleinbeck
- Center for Biomedical Research, Population Council
- Jeffrey D. Lifson
- AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research
- M. Melissa Peet
- MPI Research
- Zachary Lloyd
- MPI Research
- Michael Benson
- MPI Research
- Walid Heneine
- Centers for Disease Control
- Barry R O’Keefe
- Molecular Targets Program, Center for Cancer Research, and Natural Products Branch, Developmental Therapeutics Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute
- Melissa Robbiani
- MJR4CONSULTING
- Elena Martinelli
- Center for Biomedical Research, Population Council
- Brooke Grasperge
- Tulane National Primate Research Center
- James Blanchard
- Tulane National Primate Research Center
- Agegnehu Gettie
- Aaron Diamond AIDS Research Center
- Natalia Teleshova
- Center for Biomedical Research, Population Council
- José A. Fernández-Romero
- Center for Biomedical Research, Population Council
- Thomas M. Zydowsky
- Center for Biomedical Research, Population Council
- DOI
- https://doi.org/10.1038/s41467-018-06349-0
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 9
Abstract
Safety and efficacy remain important challenges for non-antiretroviral-based microbicides. Here, Derby et al. show that a Griffithsin-Carrageenan fast dissolving vaginal insert provides on-demand protection against SHIV infections in macaques, paving the way for the development of pre-exposure prophylaxis on-demand products.
