Research progress on basic fibroblast growth factor in promoting periodontal tissue regeneration

Abstract

Basic fibroblast growth factor (bFGF) exhibits superior biological functions by improving periodontal inflammation, promoting the migration and proliferation of periodontal-related stem cells, promoting the formation of blood vessels and periodontal ligament-like tissue, and regulating the formation of bone/cementum. It plays an important role in tooth development, repair and regeneration. bFGF can be combined with seed cells and scaffold materials for periodontal tissue regeneration, which has been verified in a number of experimental studies. However, the application of bFGF alone as a drug in clinical treatment requires further research.

Keywords

• basic fibroblast growth factor
• inflammation control
• migration
• proliferation
• angiogenesis
• periodontal ligament-like tissue
• osteogenesis/cementum
• periodontal tissue regeneration
• periodontal disease