Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Xu Zhang; Muath Bishawi; Ge Zhang; Varun Prasad; Ellen Salmon; Jason J. Breithaupt; Qiao Zhang; George A. Truskey

doi:10.1038/s41467-020-19197-8

Nature Communications (Oct 2020)

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Xu Zhang,
Muath Bishawi,
Ge Zhang,
Varun Prasad,
Ellen Salmon,
Jason J. Breithaupt,
Qiao Zhang,
George A. Truskey

Affiliations

Xu Zhang: Department of Biomedical Engineering, Duke University
Muath Bishawi: Department of Biomedical Engineering, Duke University
Ge Zhang: Department of Immunology, College of Basic Medical Science, Dalian Medical University
Varun Prasad: Department of Biomedical Engineering, Duke University
Ellen Salmon: Department of Biomedical Engineering, Duke University
Jason J. Breithaupt: Department of Biomedical Engineering, Duke University
Qiao Zhang: Department of Biomedical Engineering, Duke University
George A. Truskey: Department of Biomedical Engineering, Duke University

DOI: https://doi.org/10.1038/s41467-020-19197-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several drugs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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