Medicina Clínica Práctica (Apr 2024)
Anemia among active Helicobacter pylori infection at the University Medical Center Ho Chi Minh City: A case–control study
Abstract
Background: Helicobacter pylori (H. pylori) infection may cause gastric ulcers or extra-gastroduodenal disorders, including iron deficiency anemia. This study aimed to determine the relationship between H. pylori infection and iron deficiency anemia (IDA). Methods: A case–control study was conducted on participants aged ≥18 with an indication for gastric endoscopy. The cases were identified by positive rapid urease tests with biopsy specimens obtained during gastric endoscopy. The controls were negative rapid urease tests. Blood samples from the participants were taken for hematological indices and other iron-related parameters. Results: A total of 230 participants including 115 cases and 115 controls were eligible for the study. H. pylori positive group had significantly a lower mean value of hemoglobin (P.05). The rate of iron deficiency anemia was significantly higher in the cases than in the controls (χ2=16.05; P0.05). La tasa de anemia por deficiencia de hierro fue significativamente mayor en los casos que en los controles (χ2=16.05; p<0.001). Se encontró una asociación significativa entre la infección por H. pylori y la anemia, con OR ajustadas por edad y sexo de 7.59 (IC del 95% = 3.83-15.05, p<0.001) y 2.12 (IC del 95% = 1.05-4.25, p=0.035), respectivamente. Conclusión: Nuestro estudio encontró una asociación significativa entre la infección por H. pylori y la anemia, así como la deficiencia de hierro. La relación entre la infección por H. pylori y la anemia por deficiencia de hierro no se ha establecido de manera concluyente. Las personas infectadas con H. pylori deben ser evaluadas para detectar la IDA.
