Quantum-dot-labeled synuclein seed assay identifies drugs modulating the experimental prion-like transmission

Affiliations

Yukio Imamura: Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science
Ayami Okuzumi: Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science
Saki Yoshinaga: Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science
Akiko Hiyama: Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science
Yoshiaki Furukawa: Department of Chemistry, Keio University
Tomohiro Miyasaka: Department of Neuropathology, Faculty of Life and Medical Sciences, Doshisha University
Nobutaka Hattori: Department of Neurology, Juntendo University Graduate School of Medicine
Nobuyuki Nukina: Laboratory of Structural Neuropathology, Doshisha University Graduate School of Brain Science

Abstract

Quantum dot-labelling of preformed α-synuclein fibrils enables visualization of pharmacological effects on fibril seed spreading.