Communications Biology (Aug 2022)

Cancer cell histone density links global histone acetylation, mitochondrial proteome and histone acetylase inhibitor sensitivity

  • Christopher Bruhn,
  • Giulia Bastianello,
  • Marco Foiani

DOI
https://doi.org/10.1038/s42003-022-03846-3
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 15

Abstract

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Elevated histone density is associated with global histone acetylation, histone deacetylase inhibitor sensitivity and altered mitochondrial proteome composition, with histone regulator HMGB1 linked to histone density aberrations in many cancer cell lines.