Haematologica (May 2007)

Human leukocyte antigens HLA DRB1 influence clinical outcome of chronic lymphocytic leukemia

  • Ewa Lech-Maranda,
  • Przemyslaw Juszczynski,
  • Anna Szmigielska-Kaplon,
  • Krzysztof Jamroziak,
  • Ewa Balcerczak,
  • Tadeusz Robak

DOI
https://doi.org/10.3324/haematol.10910
Journal volume & issue
Vol. 92, no. 5

Abstract

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We investigated HLA DRB1 correlations with chronic lymphocytic leukemia (B-CLL) outcome in 90 patients. Neither of the alleles was associated with B-CLL clinical characteristics or mortality. HLA DRB1*01 and HLA DRB1*02-null were associated with shorter overall survival (p=0.007, p=0.002). Our results suggest that HLA-restricted adaptive immunity influences CLL outcome.