Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V

Shinya Rai; Hirokazu Tanaka; Mai Suzuki; J. Luis Espinoza; Takahiro Kumode; Akira Tanimura; Takafumi Yokota; Kenji Oritani; Toshio Watanabe; Yuzuru Kanakura; Itaru Matsumura

doi:10.1038/s41467-020-17666-8

Nature Communications (Aug 2020)

Chlorpromazine eliminates acute myeloid leukemia cells by perturbing subcellular localization of FLT3-ITD and KIT-D816V

Shinya Rai,
Hirokazu Tanaka,
Mai Suzuki,
J. Luis Espinoza,
Takahiro Kumode,
Akira Tanimura,
Takafumi Yokota,
Kenji Oritani,
Toshio Watanabe,
Yuzuru Kanakura,
Itaru Matsumura

Affiliations

Shinya Rai: Department of Hematology and Rheumatology, Kindai University Faculty of Medicine
Hirokazu Tanaka: Department of Hematology and Rheumatology, Kindai University Faculty of Medicine
Mai Suzuki: Division of Hematological Malignancy, National Cancer Center Research Institute
J. Luis Espinoza: Department of Hematology and Rheumatology, Kindai University Faculty of Medicine
Takahiro Kumode: Department of Hematology and Rheumatology, Kindai University Faculty of Medicine
Akira Tanimura: Department of Hematology and Oncology, Osaka University Graduate School of Medicine
Takafumi Yokota: Department of Hematology and Oncology, Osaka University Graduate School of Medicine
Kenji Oritani: Department of Hematology, International University of Health and Welfare
Toshio Watanabe: Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women’s University
Yuzuru Kanakura: Department of Hematology and Oncology, Osaka University Graduate School of Medicine
Itaru Matsumura: Department of Hematology and Rheumatology, Kindai University Faculty of Medicine

DOI: https://doi.org/10.1038/s41467-020-17666-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 14

Abstract

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Receptor tyrosine kinase mutations are frequent and associated with poor prognosis in acute myeloid leukemia (AML). Here the authors show that the antipsychotic drug chlorpromazine reduces AML cells viability by perturbing the intracellular localization of FLT3-ITD and KIT-D816V.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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