Nature Communications (Oct 2017)
αv integrins on mesenchymal cells regulate skeletal and cardiac muscle fibrosis
- I. R. Murray,
- Z. N. Gonzalez,
- J. Baily,
- R. Dobie,
- R. J. Wallace,
- A. C. Mackinnon,
- J. R. Smith,
- S. N. Greenhalgh,
- A. I. Thompson,
- K. P. Conroy,
- D. W. Griggs,
- P. G. Ruminski,
- G. A. Gray,
- M. Singh,
- M. A. Campbell,
- T. J. Kendall,
- J. Dai,
- Y. Li,
- J. P. Iredale,
- H. Simpson,
- J. Huard,
- B. Péault,
- N. C. Henderson
Affiliations
- I. R. Murray
- Department of Trauma and Orthopaedics, University of Edinburgh
- Z. N. Gonzalez
- BHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh
- J. Baily
- BHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh
- R. Dobie
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- R. J. Wallace
- Department of Trauma and Orthopaedics, University of Edinburgh
- A. C. Mackinnon
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- J. R. Smith
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- S. N. Greenhalgh
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- A. I. Thompson
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- K. P. Conroy
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- D. W. Griggs
- Center for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center
- P. G. Ruminski
- Center for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center
- G. A. Gray
- BHF Centre for Cardiovascular Science, The Queen’s Medical Research Institute, University of Edinburgh
- M. Singh
- Center for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center
- M. A. Campbell
- Center for World Health and Medicine, Saint Louis University, Edward A. Doisy Research Center
- T. J. Kendall
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- J. Dai
- Department of Pediatric Surgery, University of Texas McGovern Medical School
- Y. Li
- Department of Pediatric Surgery, University of Texas McGovern Medical School
- J. P. Iredale
- University of Bristol
- H. Simpson
- Department of Trauma and Orthopaedics, University of Edinburgh
- J. Huard
- Steadman Philippon Research Institute
- B. Péault
- BHF Centre for Vascular Regeneration & MRC Centre for Regenerative Medicine, University of Edinburgh
- N. C. Henderson
- MRC Centre for Inflammation Research, The Queen’s Medical Research Institute, University of Edinburgh
- DOI
- https://doi.org/10.1038/s41467-017-01097-z
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 13
Abstract
The mechanisms underlying tissue fibrosis are unclear. The authors show that mesenchymal cells expressing PDGFRβ mediate fibrosis in skeletal muscle and heart via a mechanism involving αv integrin, and that inhibitors of αv integrins attenuate fibrotic responses in mice.
