Nature Communications (Sep 2020)
Intercalated disc protein Xinβ is required for Hippo-YAP signaling in the heart
- Haipeng Guo,
- Yao Wei Lu,
- Zhiqiang Lin,
- Zhan-Peng Huang,
- Jianming Liu,
- Yi Wang,
- Hee Young Seok,
- Xiaoyun Hu,
- Qing Ma,
- Kathryn Li,
- Jan Kyselovic,
- Qingchuan Wang,
- Jenny L.-C. Lin,
- Jim J.-C. Lin,
- Douglas B. Cowan,
- Francisco Naya,
- Yuguo Chen,
- William T. Pu,
- Da-Zhi Wang
Affiliations
- Haipeng Guo
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Yao Wei Lu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Zhiqiang Lin
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Zhan-Peng Huang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jianming Liu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Yi Wang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Hee Young Seok
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Xiaoyun Hu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Qing Ma
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Kathryn Li
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Jan Kyselovic
- Department of Internal Medicine, Faculty of Medicine, Comenius University
- Qingchuan Wang
- Department of Biology, University of Iowa
- Jenny L.-C. Lin
- Department of Biology, University of Iowa
- Jim J.-C. Lin
- Department of Biology, University of Iowa
- Douglas B. Cowan
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Francisco Naya
- Department of Biology, Boston University
- Yuguo Chen
- Department of Critical Care and Emergency Medicine, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University
- William T. Pu
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- Da-Zhi Wang
- Department of Cardiology, Boston Children’s Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-020-18379-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
Intercalated discs ensure mechanical and electrochemical coupling during contraction of the heart. Here, the authors show that loss of Xinβ results in cardiomyocyte proliferation defects and cardiomyopathy by influencing the Hippo-YAP signalling pathway, thus affecting cardiac development and function.
