Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Jonas Malkmus; Laurène Ramos Martins; Shalu Jhanwar; Bonnie Kircher; Victorio Palacio; Rushikesh Sheth; Francisca Leal; Amandine Duchesne; Javier Lopez-Rios; Kevin A. Peterson; Robert Reinhardt; Koh Onimaru; Martin J. Cohn; Aimée Zuniga; Rolf Zeller

doi:10.1038/s41467-021-25810-1

Nature Communications (Sep 2021)

Spatial regulation by multiple Gremlin1 enhancers provides digit development with cis-regulatory robustness and evolutionary plasticity

Jonas Malkmus,
Laurène Ramos Martins,
Shalu Jhanwar,
Bonnie Kircher,
Victorio Palacio,
Rushikesh Sheth,
Francisca Leal,
Amandine Duchesne,
Javier Lopez-Rios,
Kevin A. Peterson,
Robert Reinhardt,
Koh Onimaru,
Martin J. Cohn,
Aimée Zuniga,
Rolf Zeller

Affiliations

Jonas Malkmus: Developmental Genetics, Department of Biomedicine, University of Basel
Laurène Ramos Martins: Developmental Genetics, Department of Biomedicine, University of Basel
Shalu Jhanwar: Developmental Genetics, Department of Biomedicine, University of Basel
Bonnie Kircher: Department of Biology, University of Florida
Victorio Palacio: Developmental Genetics, Department of Biomedicine, University of Basel
Rushikesh Sheth: Developmental Genetics, Department of Biomedicine, University of Basel
Francisca Leal: Department of Biology, University of Florida
Amandine Duchesne: Université Paris-Saclay, INRAE, AgroParisTech, GABI
Javier Lopez-Rios: Development and Evolution, Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de Andalucía
Kevin A. Peterson: The Jackson Laboratory
Robert Reinhardt: Developmental Genetics, Department of Biomedicine, University of Basel
Koh Onimaru: Laboratory for Bioinformatics Research, RIKEN BDR
Martin J. Cohn: Department of Biology, University of Florida
Aimée Zuniga: Developmental Genetics, Department of Biomedicine, University of Basel
Rolf Zeller: Developmental Genetics, Department of Biomedicine, University of Basel

DOI: https://doi.org/10.1038/s41467-021-25810-1
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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The BMP antagonist Gremlin1 balances BMP and SHH signalling, endowing limb bud development with robustness. Here, the authors identify enhancers controlling Grem1 levels in an additive, and spatial regulation in a synergistic manner, providing digit patterning with cis-regulatory robustness and evolutionary plasticity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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