Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

Yuning Jiang; Yanzheng Cai; Sen Hu; Xiaoyu Guo; Ye Ying; Ying Wen; Yiping Wu; Haifeng Yang

doi:10.1142/S1793545821410030

Journal of Innovative Optical Health Sciences (Jul 2021)

Construction of Au@Metal-organic framework for sensitive determination of creatinine in urine

Yuning Jiang,
Yanzheng Cai,
Sen Hu,
Xiaoyu Guo,
Ye Ying,
Ying Wen,
Yiping Wu,
Haifeng Yang

Affiliations

Yuning Jiang: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Yanzheng Cai: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Sen Hu: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Xiaoyu Guo: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Ye Ying: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Ying Wen: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Yiping Wu: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China
Haifeng Yang: College of Chemistry and Materials Science, Shanghai Normal University, Shanghai 200234, P. R. China

DOI: https://doi.org/10.1142/S1793545821410030
Journal volume & issue: Vol. 14, no. 4
pp. 2141003-1 – 2141003-9

Abstract

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Creatinine level in urine is an important biomarker for renal function diseases, such as renal failure, glomerulonephritis, and chronic nephritis. The Au@MIL-101(Fe) was prepared by in situ growth of Au nanoparticles in MIL-101(Fe) as a selective SERS substrate. The Au@MIL-101(Fe) offers the great local surface plasmon resonance (SPR) effect due to gold nanoparticles aggregation inside metal-organic frameworks. The framework structure could enrich trace target samples and drag them into SPR hot spots. The optimal Au@MIL-101(Fe) composite substrate is used for analyzing creatinine in urine and the limit of detection is down to 0.1μmol/L and a linear relationship is ranging from 1μmol/L to 100μmol/L.

Published in Journal of Innovative Optical Health Sciences

ISSN: 1793-5458 (Print); 1793-7205 (Online)
Publisher: World Scientific Publishing
Country of publisher: Singapore
LCC subjects: Technology; Science: Physics: Optics. Light
Website: http://www.worldscientific.com/worldscinet/jiohs

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