Nature Communications (Feb 2020)
Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study
- Eric M. Reiman,
- Joseph F. Arboleda-Velasquez,
- Yakeel T. Quiroz,
- Matthew J. Huentelman,
- Thomas G. Beach,
- Richard J. Caselli,
- Yinghua Chen,
- Yi Su,
- Amanda J. Myers,
- John Hardy,
- Jean Paul Vonsattel,
- Steven G. Younkin,
- David A. Bennett,
- Philip L. De Jager,
- Eric B. Larson,
- Paul K. Crane,
- C. Dirk Keene,
- M. Ilyas Kamboh,
- Julia K. Kofler,
- Linda Duque,
- John R. Gilbert,
- Harry E. Gwirtsman,
- Joseph D. Buxbaum,
- Dennis W. Dickson,
- Matthew P. Frosch,
- Bernardino F. Ghetti,
- Kathryn L. Lunetta,
- Li-San Wang,
- Bradley T. Hyman,
- Walter A. Kukull,
- Tatiana Foroud,
- Jonathan L. Haines,
- Richard P. Mayeux,
- Margaret A. Pericak-Vance,
- Julie A. Schneider,
- John Q. Trojanowski,
- Lindsay A. Farrer,
- Gerard D. Schellenberg,
- Gary W. Beecham,
- Thomas J. Montine,
- Gyungah R. Jun,
- The Alzheimer’s Disease Genetics Consortium
Affiliations
- Eric M. Reiman
- Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
- Joseph F. Arboleda-Velasquez
- Schepens Eye Research Institute of Mass Eye and Ear and the Department of Ophthalmology at Harvard Medical School
- Yakeel T. Quiroz
- Departments of Psychiatry and Neurology, Massachusetts General Hospital and Harvard Medical School
- Matthew J. Huentelman
- Neurogenomics Division, Translational Genomics Research Institute and Arizona Alzheimer’s Consortium
- Thomas G. Beach
- Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
- Richard J. Caselli
- Mayo Clinic
- Yinghua Chen
- Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
- Yi Su
- Banner Alzheimer’s Institute and Arizona Alzheimer’s Consortium
- Amanda J. Myers
- Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine
- John Hardy
- Department of Molecular Neuroscience, UCL, Institute of Neurology
- Jean Paul Vonsattel
- New York Brain Bank and Department of Pathology, New York-Presbyterian Hospital at Columbia University Medical Center
- Steven G. Younkin
- Departments of Neuroscience and Neurology, Mayo Clinic
- David A. Bennett
- Departments of Neurological Sciences and Pathology (Neuropathology), and Rush Alzheimer’s Disease Center, Rush University Medical Center
- Philip L. De Jager
- Department of Neurology, Center for Translational and Computational Neuroimmunology, Columbia University Medical Center
- Eric B. Larson
- Kaiser Permanente Washington Health Research Institute
- Paul K. Crane
- Department of Medicine, University of Washington
- C. Dirk Keene
- Department of Pathology, University of Washington
- M. Ilyas Kamboh
- Department of Human Genetics, Alzheimer’s Disease Research Center, University of Pittsburgh
- Julia K. Kofler
- Department of Pathology (Neuropathology), University of Pittsburgh
- Linda Duque
- Department of Neurology, University of Miami
- John R. Gilbert
- John P. Hussman Institute for Human Genomics, Department of Human Genetics, and Dr. John T. Macdonald Foundation, University of Miami
- Harry E. Gwirtsman
- Department of Psychiatry, Vanderbilt University
- Joseph D. Buxbaum
- Departments of Psychiatry, Neuroscience and Genetics and Genomic Sciences, Mount Sinai School of Medicine
- Dennis W. Dickson
- Department of Neuroscience, Mayo Clinic
- Matthew P. Frosch
- C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital
- Bernardino F. Ghetti
- Department of Pathology and Laboratory Medicine, Indiana University
- Kathryn L. Lunetta
- Department of Biostatistics, Boston University School of Public Health
- Li-San Wang
- Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine
- Bradley T. Hyman
- Department of Neurology, Massachusetts General Hospital and Harvard Medical School
- Walter A. Kukull
- Department of Epidemiology, University of Washington
- Tatiana Foroud
- Department of Medical and Molecular Genetics, Indiana University
- Jonathan L. Haines
- Institute for Computational Biology and Department of Population and Quantitative Health Sciences, Case Western Reserve University
- Richard P. Mayeux
- Taub Institute on Alzheimer’s Disease and the Aging Brain, Gertrude H. Sergievsky Center Department of Neurology, Columbia University
- Margaret A. Pericak-Vance
- John P. Hussman Institute for Human Genomics, Department of Human Genetics, and Dr. John T. Macdonald Foundation, University of Miami
- Julie A. Schneider
- Departments of Neurological Sciences and Pathology (Neuropathology), and Rush Alzheimer’s Disease Center, Rush University Medical Center
- John Q. Trojanowski
- Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine
- Lindsay A. Farrer
- Department of Biostatistics, Boston University School of Public Health
- Gerard D. Schellenberg
- Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine
- Gary W. Beecham
- John P. Hussman Institute for Human Genomics, Department of Human Genetics, and Dr. John T. Macdonald Foundation, University of Miami
- Thomas J. Montine
- Department of Pathology, Stanford University
- Gyungah R. Jun
- Biomedical Genetics Section, Department of Medicine, Boston University School of Medicine
- The Alzheimer’s Disease Genetics Consortium
- DOI
- https://doi.org/10.1038/s41467-019-14279-8
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
APOE is the major genetic risk factor for Alzheimer’s disease. In a large number of neuropathologically confirmed cases and controls, the impact of different APOE genotypes on Alzheimer’s dementia risk was greater than previously thought and APOE2 homozygotes had an exceptionally low risk.
