Marine Drugs (Sep 2011)

A New Anthracene Derivative from Marine Streptomyces sp. W007 Exhibiting Highly and Selectively Cytotoxic Activities

  • Song Qin,
  • Yang Pu,
  • Zeping Xie,
  • Hongli Cui,
  • Zonggang Li,
  • Hongpeng Wang,
  • Fuchao Li,
  • Hongyu Zhang

DOI
https://doi.org/10.3390/md9091502
Journal volume & issue
Vol. 9, no. 9
pp. 1502 – 1509

Abstract

Read online

A new anthracene derivative, 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene, was isolated from the marine strain Streptomyces sp. W007, and its structure was established by spectroscopic analysis including mass spectra, 1D- and 2D-NMR (1H–1H COSY, HMBC, HSQC and NOESY) experiments. 3-hydroxy-1-keto-3-methyl-8-methoxy-1,2,3,4-tetrahydro-benz[α]anthracene showed cytotoxicity against human lung adenocarcinoma cell line A549.

Keywords