The effects of Combine Training Program on Level Adipsin and Insulin Resistance in Female Multiple Sclerosis Patients (MS)

Abstract

Backgrounds and Objectives: Adipokine Adipsin is one of the important adipose tissue proteins and has a beneficial role in maintaining beta cell function. The aim of this study was to examine the effect of 12-week rhythmic combined training on plasma adipsin levels and insulin resistance in Multiple Sclerosis Patients (MS) women. Materials and Methods: In this semi-experimental study, 96 female patients with MS were selected on the basis of disability levels and divided into three groups, low disability (n=44), moderate disability (n=26) and sever disability (n=26). Training program include 12 weeks combined training, three sessions per week and 45 to 60 minute for each session. Resting levels of Adipsin and Insulin Resistance were measured 24 h before and 48 h after training programs Results: The findings showed that after 12 weeks of combine training, plasma adipsin levels in low disability group significantly decrease (p=0.002). Also, 12 weeks of combined exercise significantly decreased insulin resistance in the low and severe disability group, but no significant decrease in the group with moderate disability. Conclusions: Therefore, combine training induce changes in weight, body fat percentage, BMI and waist circumference, lipids profile and decrease the plasma adipsin level in MS women

Keywords

• women
• combine training
• adipsin
• insulin resistance
• multiple sclerosis