Nature Communications (Jan 2021)
Order and stochasticity in the folding of individual Drosophila genomes
- Sergey V. Ulianov,
- Vlada V. Zakharova,
- Aleksandra A. Galitsyna,
- Pavel I. Kos,
- Kirill E. Polovnikov,
- Ilya M. Flyamer,
- Elena A. Mikhaleva,
- Ekaterina E. Khrameeva,
- Diego Germini,
- Mariya D. Logacheva,
- Alexey A. Gavrilov,
- Alexander S. Gorsky,
- Sergey K. Nechaev,
- Mikhail S. Gelfand,
- Yegor S. Vassetzky,
- Alexander V. Chertovich,
- Yuri Y. Shevelyov,
- Sergey V. Razin
Affiliations
- Sergey V. Ulianov
- Institute of Gene Biology, Russian Academy of Sciences
- Vlada V. Zakharova
- Institute of Gene Biology, Russian Academy of Sciences
- Aleksandra A. Galitsyna
- Skolkovo Institute of Science and Technology
- Pavel I. Kos
- Faculty of Physics, M.V. Lomonosov Moscow State University
- Kirill E. Polovnikov
- Skolkovo Institute of Science and Technology
- Ilya M. Flyamer
- MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh
- Elena A. Mikhaleva
- Institute of Molecular Genetics, National Research Centre “Kurchatov Institute”
- Ekaterina E. Khrameeva
- Skolkovo Institute of Science and Technology
- Diego Germini
- UMR9018, CNRS, Université Paris-Sud Paris-Saclay, Institut Gustave Roussy
- Mariya D. Logacheva
- Skolkovo Institute of Science and Technology
- Alexey A. Gavrilov
- Institute of Gene Biology, Russian Academy of Sciences
- Alexander S. Gorsky
- Institute for Information Transmission Problems (the Kharkevich Institute), Russian Academy of Sciences
- Sergey K. Nechaev
- Interdisciplinary Scientific Center Poncelet (CNRS UMI 2615)
- Mikhail S. Gelfand
- Skolkovo Institute of Science and Technology
- Yegor S. Vassetzky
- UMR9018, CNRS, Université Paris-Sud Paris-Saclay, Institut Gustave Roussy
- Alexander V. Chertovich
- Faculty of Physics, M.V. Lomonosov Moscow State University
- Yuri Y. Shevelyov
- Institute of Molecular Genetics, National Research Centre “Kurchatov Institute”
- Sergey V. Razin
- Institute of Gene Biology, Russian Academy of Sciences
- DOI
- https://doi.org/10.1038/s41467-020-20292-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Genomes are partitioned into topologically associating domains (TADs). Here the authors present single-nucleus Hi-C maps in Drosophila at 10 kb resolution, demonstrating the presence of chromatin compartments in individual nuclei, and partitioning of the genome into non-hierarchical TADs at the scale of 100 kb, which resembles population TAD profiles.
