Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage

Mara Martín-Alonso; Sharif Iqbal; Pia M. Vornewald; Håvard T. Lindholm; Mirjam J. Damen; Fernando Martínez; Sigrid Hoel; Alberto Díez-Sánchez; Maarten Altelaar; Pekka Katajisto; Alicia G. Arroyo; Menno J. Oudhoff

doi:10.1038/s41467-021-26904-6

Nature Communications (Nov 2021)

Smooth muscle-specific MMP17 (MT4-MMP) regulates the intestinal stem cell niche and regeneration after damage

Mara Martín-Alonso,
Sharif Iqbal,
Pia M. Vornewald,
Håvard T. Lindholm,
Mirjam J. Damen,
Fernando Martínez,
Sigrid Hoel,
Alberto Díez-Sánchez,
Maarten Altelaar,
Pekka Katajisto,
Alicia G. Arroyo,
Menno J. Oudhoff

Affiliations

Mara Martín-Alonso: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Sharif Iqbal: Institute of Biotechnology, HiLIFE, University of Helsinki
Pia M. Vornewald: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Håvard T. Lindholm: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Mirjam J. Damen: Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University
Fernando Martínez: Bioinformatics Unit. Centro Nacional de Investigaciones Cardiovasculares (CNIC)
Sigrid Hoel: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Alberto Díez-Sánchez: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology
Maarten Altelaar: Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, Utrecht University
Pekka Katajisto: Institute of Biotechnology, HiLIFE, University of Helsinki
Alicia G. Arroyo: Department of Molecular Biomedicine, Centro de Investigaciones Biológicas Margarita Salas (CIB-CSIC)
Menno J. Oudhoff: Centre of Molecular Inflammation Research, and Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology

DOI: https://doi.org/10.1038/s41467-021-26904-6
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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While the role of smooth muscle in peristalsis has been studied extensively, little is known about its other functions in the intestine. Here the authors identify MMP17, expressed by smooth muscle cells, as a modulator of intestinal epithelial regeneration and the intestinal stem cell niche.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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