Communications Biology (Dec 2022)
Gut microbiota modulates lung fibrosis severity following acute lung injury in mice
- Ozioma S. Chioma,
- Elizabeth K. Mallott,
- Austin Chapman,
- Joseph C. Van Amburg,
- Hongmei Wu,
- Binal Shah-Gandhi,
- Nandita Dey,
- Marina E. Kirkland,
- M. Blanca Piazuelo,
- Joyce Johnson,
- Gordon R. Bernard,
- Sobha R. Bodduluri,
- Steven Davison,
- Bodduluri Haribabu,
- Seth R. Bordenstein,
- Wonder P. Drake
Affiliations
- Ozioma S. Chioma
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Elizabeth K. Mallott
- Department of Biological Sciences, Vanderbilt University
- Austin Chapman
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Joseph C. Van Amburg
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Hongmei Wu
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Binal Shah-Gandhi
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Nandita Dey
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- Marina E. Kirkland
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- M. Blanca Piazuelo
- Division of Gastroenterology, Hepatology and Nutrition Research, Department of Medicine, Vanderbilt University School of Medicine
- Joyce Johnson
- Department of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine
- Gordon R. Bernard
- Division of Pulmonary and Critical Care, Department of Medicine, Vanderbilt University School of Medicine
- Sobha R. Bodduluri
- Department of Microbiology and Immunology, University of Louisville School of Medicine
- Steven Davison
- Comparative Medicine Research Unit, University of Louisville School of Medicine
- Bodduluri Haribabu
- Department of Microbiology and Immunology, University of Louisville School of Medicine
- Seth R. Bordenstein
- Department of Biological Sciences, Vanderbilt University
- Wonder P. Drake
- Division of Infectious Disease, Department of Medicine, Vanderbilt University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-022-04357-x
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 13
Abstract
Direct modulation of the gut microbiota via rearing environments and fecal microbiota transplantation in a bleomycin-induced murine model suggests that a functional gut-lung axis modulates lung fibrosis.
