STAR Protocols (Sep 2021)
Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction
Abstract
Summary: Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations.For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021)